In Brief:
Two recent studies, one published in the Journal of Investigative Dermatology and the other in the British Medical Journal, suggest having severe acne increases risk of suicide.. Having acne is tough and severe acne can be devastating for some people, especially teens.. What is interesting is that both studies show that the risk of suicide increases independent of isotretinoin (also known as Accutane) use.. This doesn't mean that isotretinoin is off the hook. What it does mean is that we need to be aware that just having acne can increase risk of depression, increase risk of suicide, regardless of whether or not isotretinoin is being used..